Abstract

The research objective is to optimize excipient ingredients in the preparation of tablets containing curcumin spray-dried powder. Using the response surface method (RSM) combined with the central composite design (CCD) through Design Expert 13 software, including 19 experiments and independent variables: Lubricant content: magnesium stearate (%), content of disintegrant: crospovidone (%), and content of binder: PVP-K30 (%); The dependent variable investigated was the solubility of curcumin at 45 min. The parameters of the optimal process are verified experimentally, and some quality indicators are investigated. The results showed that the optimal parameters of the process include magnesium stearate content of 1.083%, crospovidone content of 3.106%, and PVP-K30 content of 2.000%. Tablets using the above optimal values gave solubility results consistent with software predictions and were 120% and 140% more effective than the solubility of spray-dried powder and raw curcumin, respectively. Besides, the optimized tablets also meet the tablet quality criteria mentioned in Vietnamese Pharmacopoeia V. Through this research, the formulation of tablets containing curcumin spray-dried powder has been optimized on a laboratory scale, which is the foundation for moving towards industrial-scale production.